Breast cancer survival unaffected by faulty gene

Having a mutated BRCA gene- as famously carried by Angelina Jolie- dramatically increases the chance a woman will develop breast cancer in her lifetime from 12 per cent to 90 per cent

According to the paper, this is the largest study of its kind to look at breast cancer outcomes based on a woman's BRCA mutation status.

"This important topic needs more prospective research as preventive surgical measures might have an effect on what might be a very long life after a diagnosis of breast cancer at a young age", wrote Peter Fasching, MD, of Friedrich-Alexander University Erlangen-Nuremberg, Germany, in an editorial published with the study. The faulty gene increases the risk of a woman developing breast and ovarian cancers, with 45% to 90% of women with the mutation developing breast cancer during their lifetime, compared to roughly 12.5% of women in the general population.

Have you been diagnosed with breast cancer and carry the BRCA gene mutation?

Young women with the BRCA gene mutation that prompted actress Angelina Jolie's pre-emptive and much-publicised double mastectomy are not more likely to die after a breast cancer diagnosis, scientists said Friday.

Young breast cancer patients with faulty BRCA genes have the same survival chances as those without, a study has found. This was true at 2, 5 and 10 years following diagnosis. These findings remained similar regardless of whether mutations were in the BRCA1 or BRCA2 gene.

"It can be hard for some patients to decide whether or not to have risk-reducing surgery, typically double mastectomies and removal of ovaries".

More news: India, Pakistan held NSA-level talks in Thailand in December: MEA

"Our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment".

She added: "In view of this, younger women with breast cancer can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk reducing strategy".

"In particular, being able to give some women with triple negative breast cancer the choice to delay a risk-reducing mastectomy would allow them to take back control of a major part of their treatment and offer them more time to recover from their initial therapy".

A subgroup analysis of 558 patients with triple-negative breast cancer, however, did show a significant survival advantage during the first few years after diagnosis in BRCA mutation carriers.

Eccles and her colleagues noted that the findings might not apply to older breast cancer patients with a BRCA mutation.

In the trial, Lynparza - developed with Merck & Co Inc - significantly prolonged progression-free survival compared with chemotherapy, and reduced the risk of disease progression or death by 42%. "These risks determine treatment, and knowing that BRCA1 or BRCA2 mutations do not result in a different prognosis might change the therapeutic approach for these risks". The FDA says it is expanding approval of Lynparza (olaparib) to include use against BRCA-linked tumors that have spread outside the breast.

Related News:

  • Governor Cooper urges Trump Administration to exempt NC from offshore drilling plan

    Governor Cooper urges Trump Administration to exempt NC from offshore drilling plan

    If exceptions are being made for other states, the governor will certainly pursue the same type of exception for New Jersey. Scott called the meeting with Zinke "historic" and thanked him for reversing the decision.
    Putin Says NKorea's Kim 'Won This Match' on Nukes Over SKorea, US

    Putin Says NKorea's Kim 'Won This Match' on Nukes Over SKorea, US

    When asked if his relationship with Bannon is permanently broken, Trump stated, "I don't know what the word permanent means". Trump has always been trading insults with Jong-un over this issue.
    (NYSE:JPM) reported earnings of $1.76 per share beating Walls Streets expectations

    (NYSE:JPM) reported earnings of $1.76 per share beating Walls Streets expectations

    Turning to TransCanada Corporation (NYSE:TRP), its shares were trading at $47.47 a retreat of $-1.48, on the trading floor. Arrow invested in 1.65% or 72,667 shares. 9,968 shares were sold by Friedman Stacey , worth $902,608 on Monday, August 21.
  • Analysts See $1.94 EPS for Amazon.com, Inc

    Following the sale, the chief executive officer now directly owns 10,000 shares of the company's stock, valued at $11,603,400. Following the transaction, the director now directly owns 18,460 shares in the company, valued at approximately $20,475,832.
    US Air Force sends B-2 bombers and 200 Airmen to Guam

    US Air Force sends B-2 bombers and 200 Airmen to Guam

    The last time one of the stealth bombers flew near the Koreas was during a rare show of force over the peninsula in 2013. The announcement was tweeted this morning and refers to the missions being a "bomber assurance and deterrence mission".
    Auto  bomb kills 18 in Syrian rebel-held city

    Auto bomb kills 18 in Syrian rebel-held city

    All of the Syrian troops who survived the battle - some 71 by most reports - were promptly executed by their captors. A child and two other civilians were also killed in strikes on the small town of Madira, the Observatory said.
  • Tina Smith, Doug Jones Sworn In To US Senate; GOP Majority Shrinks

    Tina Smith, Doug Jones Sworn In To US Senate; GOP Majority Shrinks

    Biden campaigned for Jones in Alabama and recorded a robocall for his fellow Democrat in the final days of the campaign. Biden will speak afterward to a gathering of Jones' friends and family, a person familiar with his plans said .
    Saints march into divisional round with win over Panthers

    Saints march into divisional round with win over Panthers

    The rules changed, but the Carolina Panthers may not have. "We wouldn't rather have anybody commanding our offense", Ingram said. Running back Adrian Peterson was traded after four games. "I thought there was a receiver (Devin Funchess) in the vicinity".
    Turkey says U.S.  court verdict an 'interference in domestic affairs'

    Turkey says U.S. court verdict an 'interference in domestic affairs'

    Although US prosecutors have criminally charged nine people, only Zarrab and Atilla have been arrested by US authorities so far. The bank fraud counts each carry a maximum term of imprisonment of 30 years.
  • Radon Action Month good time to test your home

    Radon Action Month good time to test your home

    Short-term radon detection kits are available for $10 at Teton County Environmental Health in the public health building at 460 E. Over 20,000 Americans suffer from radon-related cancer each year, and it causes up to 15 percent of lung cancers worldwide.
    Carphone Warehouse fined £400000 for customer data breach

    Carphone Warehouse fined £400000 for customer data breach

    The company was accused by the ICO of failing to adequately secure its systems, enabling intruders to easily access the data.
    Rebekah Shelton is NOT dead

    Rebekah Shelton is NOT dead

    She recently she made an appearance on ITV's Judge Rinder where she appeared to try and claim money back for a botched boob job. Taking to Twitter she deleted the previous tweet in which her death was announced and replaced it with "I'm not dead! ".


Most liked

Monaco boss Jardim tempts Liverpool into huge Lemar bid
According to the Daily Mail , Premier League sides Arsenal and Liverpool are both reportedly interested in the French worldwide . Monaco are not totally against the idea of an offer this month, but it would have to be a very big offer.

European Court of Justice advisors say gay spouses have equal rights
The couple, who met in NY in 2002 and are both 46, married in Belgium in 2010 after living together for four years in the US. The case involves a Romanian male national who had married a man from the United States in Brussels in 2010.

Van Jones on Oprah's 2020 chances: 'She can do it'
It's tempting to see all this attention paid to Oprah and say, "Hey, at least she'd be better than Trump". "I know her very well". The person emphasised that the star had not made up her mind about running. "But I don't know a lot about politics".

Intel fabricates 49-qubit test chip for partner QuTech
In addition to Intel firmware updates, the Meltdown and Spectre flaws also generally require operating system updates. Krzanich showed off another new chip during his keynote, and it's a doozy: A 49-qubit chip for quantum computing.

John Cena Makes His Big Announcement
The series is produced by ITV Entertainment and Hard Nocks South, based on a United Kingdom format from Possessed. After each game, a 360-degree scanner will measure each teams' mess to determine just how clean they really are.

LSU RB Derrius Guice, Likely Early-Round Pick, Declares for NFL Draft
In sharing time with Fournette, Guice tallied 1,493 total yards and 16 touchdowns at a clip of 7.6 yards per rush back in 2016. That announcement coming via a heartfelt video message from the running back and Baton Rouge-native on Wednesday.

Unregistered Independent Church's Building Demolished by Chinese Communist Government
United States government-backed Radio Free Asia says the church had come under strict monitoring by local authorities. This is not the first time Golden Lampstand Church has faced persecution, however.

Wisconsin Teacher Reportedly Asks Students To List "3 Good Reasons For Slavery"
The school's principal, Jim Van Dellen , and the senior pastor, Andrew Steinke, did not return calls from the AP yesterday. Wednesday, administrators from Our Redeemer Lutheran School responded apologized for a fourth-grade homework assignment.

Real Madrid dominate UEFA fans' team of 2017; PSG's Neymar misses out
Paris Saint Germain stars; Neymar Jr Da Silva and Kylian Mbappe as well as Tottenham's Harry Kane were not picked for the team . Other top players included in the team are Kevin de Bruyne , Eden Hazard , Sergio Ramos, Marcelo and Toni Kroos.

California state budget: Here's why to hold the applause for Brown
Brown sent this annual budget proposal to the California Legislature Wednesday for the sixteenth and final time. Brown's new General Fund budget is a record $131.7 billion, a 4.1% increase over a year ago .

LG starts rolling out Android Oreo update for LG G6 users
Being a high-end Smartphone, OnePlus 5T smartphone offers all advanced features to explore what you might have dreamed of. Recently, the company rolled out the stable version of Android 8 .0 Oreo for its LG V30 smartphone in South Korea.

Bitcoin jumps as Peter Thiel reportedly amasses 'hundreds of millions'
In October , he called Bitcoin the gold in the cyber age at an event in Riyadh, Saudi Arabia. Thiel has, in the past, spoken positively about the cryptocurrency.

Sorry men, scientists say ibuprofen may be bad for your testicles
These are the findings of a new study published on Monday in the journal " Proceedings of the National Academy of Sciences ". At the same time, the ratio of testosterone to luteinising hormones decreased, which is a sign of dysfunctional testicles.

Christian Pulisic Says LeBron James a 'Big Inspiration' for Him
Pulisic himself puts his improvement as a player down to the fact he has been given so much game time at Dortmund. Pulisic won the US Soccer Federation's Male Player of the Year award last month.

Hina Khan speaks bad about Shilpa Shinde and disappoints yet again
Now, after nearly two years Shilpa grabbed huge eyeballs on the reality show with fans really liking the kind of person she is. Vikas Gupta deserves a win? In his interview to Mumbai Mirror, he said, "Shilpa Shinde will win the show".